| CASE REPORT |
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| Year : 2021 | Volume
: 4
| Issue : 3 | Page : 57-61 |
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Glioblastoma multiforme of the conus medullaris with leptomeningeal dissemination that presented as intracranial hypertension: A case report and literature review
Yu Hu1, Wumeng Yin2, Junpeng Ma1, Jiagang Liu1, Siqing Huang1, Haifeng Chen1
1 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
2 West China college of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
Correspondence Address:
Dr. Haifeng Chen
Department of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan Province
China
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/glioma.glioma_15_21
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Spinal glioblastoma multiforme (GBM) that originates from the conus medullaris is rare as only 28 cases have been reported. It is highly aggressive and usually initially presents with low back pain, sensory and motor impairment of the lower extremities, and bladder dysfunction. We herein report a unique case of GBM in the conus medullaris with leptomeningeal dissemination that initially presented with increased intracranial pressure without hydrocephalus. The patient was first diagnosed with tuberculous meningitis and received antituberculosis therapy, but the symptoms did not resolve and even worsened. Subsequent radiological imaging clearly disclosed an intramedullary lesion at the T12 level with the progression of leptomeningeal enhancement. Subtotal resection of the intramedullary lesion was performed, and pathological examination revealed the presence of GBM. To our knowledge, our case was the first with holocordal and intracranial leptomeningeal dissemination that initially presented with intracranial hypertension in the absence of hydrocephalus. Awareness of this unusually lethal condition is significant for proper diagnosis, timely treatment, and consideration of clinical prognosis.
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