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Year : 2023  |  Volume : 6  |  Issue : 1  |  Page : 9-14

Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review

Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer, Kunming, Yunnan Province, China

Correspondence Address:
Dr. Wei Ni
No. 519, Kunzhou Road, Xishan, Kunming 650000, Yunnan Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/glioma.glioma_3_23

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Glioblastoma is the most common malignant tumor in the adult primary central nervous system. It has a strong proliferative ability, high recurrence rate, and high malignant degree. Despite standard radiotherapy combined with temozolomide chemotherapy, the prognosis was poor, with a 5-year survival of <10%. Therefore, more effective treatments need to be explored. Oncolytic viruses (OVs) have attracted the attention of researchers because of their unique targeting, safety, and antitumor effects. OV therapy has achieved remarkable efficacy in the treatment of many kinds of malignant tumors, and it has also made great progress in the treatment of glioblastoma. This article reviews the recent clinical research progress of OVs in the treatment of glioblastoma.

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