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  Indian J Med Microbiol
 

Figure 3: Tubastatin A induces apoptosis in U87MG glioblastoma cells and shows a synergistic effect with TMZ as a combination treatment (Caspase-Glo 3/7 assay at 24, 48, and 72 h). Data are presented as the mean ± SD from n = 4 independent samples assayed in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, vs. control; #P < 0.05, vs. TMZ (one-way analysis of variance followed by Tukey's post hoc test). A405: Absorbance at 405 nm, A492: Absorbance at 492 nm, Cyp: Cyclopamine, RLU: Relative light units, SD: Standard deviation, TMZ: Temozolomide, Tub A: Tubastatin A

Figure 3: Tubastatin A induces apoptosis in U87MG glioblastoma cells and shows a synergistic effect with TMZ as a combination treatment (Caspase-Glo 3/7 assay at 24, 48, and 72 h). Data are presented as the mean ± SD from <i>n</i> = 4 independent samples assayed in triplicate. *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001, ****<i>P</i> < 0.0001, vs. control; #<i>P</i> < 0.05, vs. TMZ (one-way analysis of variance followed by Tukey's <i>post hoc</i> test). A405: Absorbance at 405 nm, A492: Absorbance at 492 nm, Cyp: Cyclopamine, RLU: Relative light units, SD: Standard deviation, TMZ: Temozolomide, Tub A: Tubastatin A